Appointed as Consultant Coloproctologist to Good Hope Hospital (now part of University Hospitals, Birmingham) and Honorary Senior Lecturer at Birmingham University in 1998. He trained at Gonville & Caius College, Cambridge University and the Royal London Hospital. Prior, to his Consultant appointment, he was Lecturer in Surgery at Queens Medical Centre, Nottingham.
In 1998, the Royal College of Surgeons of England appointed him Hunterian Professor, for his research into colonic flora and inflammatory bowel disease.
He has an interest in disorders of defaecation and the pelvic floor. He established the pelvic floor service at Good Hope Hospital as well as introducing a number of new techniques to treat these problems such as sacral nerve stimulation. He is a founding member of the Pelvic Floor Society.
Mark is Joint Cancer Lead for University Hospitals and responsible for governance and ensuring best practice is followed in cancer treatment. He was chair of the Specialised Colorectal Clinical Reference Group for NHS England until 2019 and has recently demitted as chair of the External Affairs Committee.